Global TB Reporting Has No Standard 'End-to-End Cure Fraction' Indicator, So Coverage Gaps Stay Invisible
Problem Definition
WHO's headline indicator for drug-resistant tuberculosis is 'treatment success rate' -- the share of enrolled patients who are cured -- and in 2024 that number improved to 71%, up from 68%.
What that indicator does not report, anywhere in the standard fact sheet, is that only 42% of the estimated 390,000 people who developed multidrug- or rifampicin-resistant TB that year were ever enrolled in treatment at all. Multiply the two figures and the true population-level cure fraction is roughly 30%, not 71%.
This is not a WHO-specific failure -- it's a structural feature of how most global health programs report outcomes: success rate among the treated, not success rate among the sick. The gap matters because it changes the policy conversation entirely. A 71% success rate says 'the treatment works, keep funding regimen R&D.'
A 30% end-to-end cure fraction says 'the treatment works but almost nobody who needs it is getting it, so the marginal dollar belongs in case-finding and formulary access, not in another clinical trial.'
Countries and donors currently have no standardized, mandatorily-reported indicator that combines incidence, diagnostic yield, treatment initiation, and treatment success into one number. Each piece is measured by a different part of the health system, on a different reporting cycle, and nobody is institutionally responsible for multiplying them together.
The result is that genuinely excellent treatment science (BPaLM cuts DR-TB therapy from ~18 months to 6, all oral) gets celebrated in isolation from the fact that formulary and procurement barriers mean only 3 of 18 surveyed European countries had full pretomanid availability as of the most recent survey.
The same blind spot almost certainly exists in HIV, hepatitis C, and cervical cancer screening programs, anywhere a 'success among the treated' metric is reported without its companion 'share of the sick who got treated' metric sitting next to it on the same dashboard.
Root Causes
Incidence estimation (epidemiological modeling) and treatment outcome tracking (clinical/programmatic reporting) sit in different institutional units with different reporting cadences, so nobody owns the multiplication
Headline indicators are chosen partly for donor communications value, and 'success rate' trends look better and are easier to improve marginally than a combined coverage-adjusted metric
Diagnostic and enrollment gaps are financing and procurement problems, not clinical ones, so they compete poorly for research funding and prestige against regimen science
No international body currently mandates joint reporting of coverage and success rate as a single composite indicator across TB, HIV, or other chronic infectious disease programs
Scope
Discussion
Discussion (1)
Vanity metrics mask systemic failure.
